andy/ August 26, 2019/ medication for visual impairments, Uncategorized/ 0 comments

HETLIOZ: Non-24-Hour Sleep-Wake Disorder (Non-24) is a serious, chronic disorder that disrupts a person’s circadian rhythms. Non-24 affects up to 70% of people who are totally blind, whether you were born blind or became so later in life.

Everyone has an internal circadian clock, or body clock, which runs a little longer than 24 hours. For sighted people, it is reset every day by environmental light cues. For people who are totally blind and unable to perceive light, the body clock and sleep-wake cycle can become out of sync with the 24-hour day-night cycle.

So with Non-24, you experience a constant daily shift in the times when your body expects to sleep and be awake, creating periods when you may be awake at night and want to sleep during the day.

HETLIOZ® (tasimelteon) is the first and only medication proven to treat Non-24. There’s an FDA-approved therapy that may help you sleep at night and stay awake during the day.

Ask your doctor about the first and only treatment for people who are totally blind with Non-24, called HETLIOZ® (tasimelteon). Remember to tell your healthcare provider about all of the medicines you’re taking. HETLIOZ® should not be taken in combination with fluvoxamine or rifampin.

What is Non-24?
Non-24 is a serious, chronic disorder that affects a person’s circadian rhythms. It can arise at any age, and as many as 70% of people who are totally blind suffer from Non-24.

People with Non-24 who are totally blind lack the light perception necessary to synchronize the circadian clock with the 24-hour day-night cycle.

What is my internal clock/circadian clock?
The internal circadian clock is your body’s natural timing mechanism. For most people, sighted or blind, it runs a little longer than 24 hours. In other words, most people’s natural rhythms actually cycle a bit longer than the 24-hour day.

Because people who are sighted are able to perceive light, the brain aligns their rhythms each day with the 24-hour cycle. Light is the main environmental cue that signals the brain to reset the master body clock to the 24-hour day. But if you are totally blind and don’t have light perception, you may be unable to sync your internal clock with the 24-hour day.

With Non-24, every day there’s a shift—later and later—in the times when your body expects to sleep and be awake. Eventually, day becomes night and night becomes day. Your sleep-wake cycle will continue to shift. So, you will briefly line up with the 24-hour day, only to have the cycle of misalignment start all over again.

Who do I talk to if I think I, or someone I know, has Non-24?
If you think you have Non-24, talk to your doctor or other healthcare professional. If you have a friend or loved one who may have Non-24, advise them to speak with a healthcare professional.

If your doctor is not familiar with Non-24-Hour Sleep-Wake Disorder, refer him or her to

If you need help finding a doctor, HETLIOZSolutions™ may be able to help. Call 1-844-HETLIOZ. That’s 1-844-438-5469, Monday through Friday, 9AM to 8PM, Eastern Standard Time. Learn more about HETLIOZSolutions™.

You are encouraged to report side effects of prescription drugs to the FDA. Visit, call 1-800-FDA-1088, or report by fax at 1-800-FDA-0178.

For more information, ask your doctor or call 1-844-HETLIOZ (1-844-438-5469).

This information does not take the place of talking with your doctor for medical advice about your condition or treatment.

You can also hear the full Prescribing Information by calling 1-844-HETLIOZ (1-844-438-5469).


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